Журнал болезней крови и переливания крови

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The Role of Novel Biomarker in Early Prediction of Preeclampsia in Pregnant Rats

Manar E Selim,Nouf G Elshmry and E Himaidi A Rashed

Preeclampsia has been known to be implicated in almost 20% of pregnancy-related maternal deaths and is also known to be the leading cause of a mandated preterm delivery. Pre-eclampsia is a medical condition associated with significant amounts of protein in urine in pregnant ladies reported with hypertension. As this is not a normal situation, the need for development of relevant biomarkers, rapid improvement in current diagnosis and the advancements in treatment is greatly required. The Cellular microparticles are either shed or secreted from cell membranes as endocytic vesicles which are termed as exosomes. In our investigation, evidence of accumulating exosomes in preeclamptic rats that modulate the antigen presentation, and are also capable of suppressing the immune response by exposing NkG2D-ligands has been investigated. The probability of such research on these vesicles and their putative clinical relevance are quite exciting and promising for the future upcoming research. The faster the disease is detected and confirmed with the help of such vesicles, the better would the maternal and fetal prognosis be diagnosed.