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The Clinical Importance of Drug Monitoring: Methotrexate-Induced Acute Renal Failure

Arlette G Delgado, Jose A Vera, Maria A Moyano and Maria I Serrano

Plasma concentrations of methotrexate (MTX) represent the best predictive value of its toxicity. Monitoring of the MTX is a common practice that allows identifying patients with acute toxicity and adjusting the dose of folinic acid, and establishing immediate corrective actions. However, the main adverse effects that must be found after a patient treated with this drug are myelosuppression, mucositis of the entire gastrointestinal tract, renal failure and in some cases neurological alterations.