Фармацевтика Аналитика Акта

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Synthesis and Adsorption Performance of Molecularly Imprinted Microspheres for Quercetin by Suspension Polymerization

Yanbin Yun, Minghang Zhu, Zhimiao Zhang, Chao Liu, Jiandu Lei, Guanghui Ma and Zhiguo Su

The preparation of molecularly imprinted microspheres for quercetin by aqueous suspension polymerization was first presented, in which quercetin is used as template molecule, methacrylic acid as functional monomer and ethylene glycol dimethacrylate as cross-linker. Morphological of the imprinted microspheres for quercetin was characterized by scanning electron microscopy. The imprinting effect of the imprinted microspheres was evaluated, and selectivity analysis suggests that the imprinted microspheres can selectively recognize quercetin from its structure analogues. In addition, adsorption kinetics and adsorption isotherm are used to investigate the binding characteristics of the imprinted microspheres. Results indicate that quercetin can be adsorbed rapidly by the imprinted microspheres, and the maximum theoretical static binding capacity is up to 96.5927 mg g-1.