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"Symbiotic" Hemofiltration: New System for Chronic Renal Failure Compensation

Yumatov EA

Widely used nowadays hemodialysis and hemofiltration cannot replace completely the excretory function of human kidneys in natural conditions of physiological regulation. Healthy human kidneys are capable to purify patient’s blood from uremic substances better than any artificial device with no doubt. Previously, we proposed a "method of "symbiotic "compensation of chronic renal failure (CRF) in humans", based on the use of healthy human kidneys natural physiological function to purge patient’s blood plasma from waste substances subjected to be excreted. In the method, the clearance of blood plasma from metabolites in CRF patients is based on the temporary association of healthy human and patient’s circulations. The disadvantage of this method is to mix the blood of a patient and a healthy person. Therefore, this method has certain limitations associated with the necessity of a careful partner’s selection with the absolute blood type compatibility. The aim of our study is to develop and create a new method and apparatus for CRF patients "symbiotic" compensation, based on hemofiltration and healthy humans kidneys natural physiological functions, excluding mixing of partners blood. Method of "symbiotic" hemofiltration is based on mutual exchange of equivalent blood ultrafiltrate volumes between healthy person and CRF patient, needed to be purified from metabolites. During exchange procedure patient’s and a healthy person’s circulations are separated by hemofilters excluding blood mixing. During CRF patient’s blood clearance from metabolic products separate hemofiltration of healthy donor and CRF patient in equal volumes is processed. Patient's blood ultrafiltrate enters the bloodstream of a healthy person, as a healthy person ultrafiltrate in the same extent (volume) enters the bloodstream of CRF patient. At the same time remaining after filtration blood components of donor and patient are returned in their bloodstream respectively. Fundamentally important advantage of "symbiotic" hemofiltration is that CRF patient’s blood is purged from uremic metabolites due to healthy human kidneys natural physiological functions. "Symbiotic" hemofiltration is a highly effective physiological method of CRP patient’s blood purification from the uremic substances.