Журнал исследований и терапии стволовых клеток

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Stem Cells Therapy in Diabetes Mellitus

Yang Xi and Shizhong Bu

Diabetes is one of the top 10 leading causes of morbidity and mortality, affecting nearly 350 million people worldwide. β-cell replacement represents an attractive prospect for diabetes therapy but treatment options remain quite limited. There is increasing hope placed on insulin producing cells derived from human pluripotent stem cells, even as the approach faces continued challenges. The most effective protocols thus far have produced cells that express insulin, and have molecular characteristics that closely resemble genuine insulin-secreting cells. However, these cells demonstrate little sensitivity to glucose – an issue that will hopefully be resolved in coming years. This review summarizes recent progress in obtaining cells that express insulin from different progenitor sources, and highlights the major pathways and genes involved in diabetic patients.