Журнал тропических болезней и общественного здравоохранения

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Role of Genes in Reversing Antibiotic Resistance

Mandeep Kaur, Satish Gupte and Tanveer Kaur

Bacteria have evolved to overcome a wide range of antibiotics and resistance mechanisms against most of the conventional antibiotics have been identified in some bacteria. Pathogen resistance to antibiotics is a rapidly growing problem and development of new antibiotics faces numerous obstacles. To reverse the antibiotic resistance phages are used as a genetic tool to increase bacterial susceptibility to antibiotics. Genes are also used to reverse antibiotic resistance in certain pathogens. In this review article the uses temperate phages to introduce, by lysogenization, the genes rpsL and gyrA conferring sensitivity in a dominant fashion to two antibiotics, streptomycin and nalidixic acid, respectively. The use of phages with genes restores antibiotic efficiency by reversing pathogen resistance