Yujun Feng, Huimin Zhang, Ming Cao and Changjun Wang
Streptococcus suis (S. suis), comprising thirty-five different serotypes, is a complex group of bacterial species that are not only pathogenic to pigs but also cause opportunistic infections in humans. The repertoire of virulence determinants has been largely elucidated, contributing to a better understanding of the pathogenesis underlying severe S. suis infections. Here, we focus on the control of S. suis virulence by a rainbow coalition of regulators and discuss future perspectives in this field. This may provide insights into the complex network of virulence regulation in S. suis.