Журнал микробных и биохимических технологий

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Physiological Changes in Salivary Gland and Kidney that help the Diagnosis caused of Epstein-Barr virus: A Brief Review

Caetano LP, Costa KCT, Moraes ABA and Alves-Balvedi RP

Epstein-Barr virus (EBV) also called human herpes virus 4 (HHV-4) is a member of the Herpesviridae family. It is estimated that about 90% of the world population is infected, asymptomatically, with at least one subtype of this family. The primary EBV infection is characterized by infectious mononucleosis, popularly known as kissing disease. A few years ago the virus has been linked to several diseases among which stands out the autoimmune diseases and several types of cancer and agent of severe tissue injury and it is a kidney and saliva physiology modulator. The diagnosis of EBV described in literature basically occurs by techniques of in situ hybridization and polymerase chain reaction (PCR) of viral DNA present in collected venous blood. But this review propose demonstrate that the use of other physiological fluid, such as saliva and urine, was done a survey of less invasive detection tests. These tests are used in dynamic and emerging nanotechnology because they help in the diagnosis of diseases based on the detection of biomarkers and broaden perspectives in clinical diagnosis, prognostic and monitoring of diseases, contributing to patient care. The use of such fluids in addition to relative ease of collection is an alternative for the diagnosis is very attractive especially by the less invasive nature of the venipuncture or biopsy.