Фармацевтика Аналитика Акта

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Obesity and Niemann-pick-diseases 2: Pathogenesis and Bioinformatics Correlations

Abdulkadir Y. Maigoro*, arba M. Khalid

Interest to understand the molecular pathogenesis of obesity is on the rise, since the disease is becoming of global health concerns with consequences of moribundity, other complications and mortality. However, little is known about the pathogenesis association between obesity and the Neimann-pick diseases. This review therefore critically discusses the classical types of obesity with focus on its genetic links with the Neimann-pick diseases in terms of pathogenesis, associated proteins, signaling pathways and bioinformatics analysis. We analyzed the sequence similarity network between the reported genes found implicated in the two diseases pathways respectively. Two nodes of MC/4R-ERK and APPL1 were found connected, an indication of similarity sequence wisely and probably sharing similar cellular function in relation to obesity and Nieman’s Pick disease which could be in a similar way with NPC2.