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New Antibacterial Agents must, but Easy-to-Implement Assays First

Boobalan Pachaiyappan

Therapeutic validation of peptidyl-tRNA hydrolase (Pth) inhibition to discover novel antibacterial drug scaffolds is encumbered by lack of medicinal chemistry efforts and a simple easy-to-implement assay procedure for the analysis of Pth activity. In this issue, Holloway et al. have demonstrated that such a quantification assay is possible. This should speed-up inhibitor screening for identification of novel hits.