Глобальный журнал биологии, сельского хозяйства и медицинских наук

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Neuromuscular Electrical Stimulation and Biofeedback Therapy to Improve Endometrial Growth in Patients with thin Endometrium: A Randomized Controlled Study

Madafeitom Meheza Abide Bodombossou Djobo, Na Di, Xiaoli Chen, Zhuangyu He, Xiaomiao Zhao, Shaoqing Chen, Qingxue Zhang & Dongzi Yang

To evaluate the efficacy of noninvasive Neuromuscular electrical stimulation (NMES) in thin endometrium treatment, 115 patients (endometrium thickness ≤7mm) were recruited and randomly allocated to two groups. NMES group received NMES 3 to 4 times from day 9-10 and in comparison, a similar group received aspirin. Pre and posttreatment endometrium thickness, endometrial volume and Power Doppler Angiography (PDA) related parameters were measured by three-dimensional ultrasound. The endometrium was thicker in the NMES group compared with that in aspirin group [8.00 versus 7.72; P=0.028]. The endometrial and sub-endometrial volumes at final point also differ significantly between groups [2.58 versus 2.28; P=0.008 and 1.40 versus 1.21; P=0.001 for endometrial volume and subendometrial volume respectively. Endometrial flow index (FI), sub-endometrial vascularization index (sub-VI), subendometrial flow index (sub-FI) and sub-endometrial vascularization flow index (sub-VFI) differed statistically between groups (P=0.032, P=0.022, P=0.006 and P=0.018 respectively). In conclusion, NMES group showed better endometrial thickness, volume and vascularization than aspirin group.