Журнал сосудистой медицины и хирургии

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Natural Killer Cell Phenotype at Diagnosis of Acute Lymphoblastic Leukemia Predicts Disease Prognosis

Anil Kumar, Srividya Swaminathan*

Studies on Natural Killer (NK) cells have demonstrated their potential in treating hematological malignancies and solid tumors. Because they are potentially safer and easier to engineer than T cell-based therapies, NK cells are a particularly attractive platform for developing off-the-shelf cellular treatments. Development of allogeneic NK cellbased therapies requires a detailed understanding of how autologous NK cells are suppressed in patients with cancers.