Геронтология и гериатрические исследования

Абстрактный

Modulation of Nutrient-Responsive Pathways in Lifespan and Health

Charalampos Frisardi

Studies in bio gerontology are driven by cellular, tiny invertebrate and vertebrate models. Our understanding of the connection between nutrition, nutrient-response signalling pathways, and lifespan control has greatly expanded because to the use of many models, including yeasts, suitable tissue culture cells, Drosophila, the worm Caenorhabditis elegant, and the mouse. In recent years, high-throughput screens, mutagenesis, combinatorial pharmacological therapies, and multi-omics methods have all contributed to the discovery of previously unheard-of understandings of cellular metabolism, differentiation, and ageing. Hence, in order to find potential therapies that might promote healthy ageing and the amelioration of age-related disorders in humans, scientists are working to characterise the intricate architecture and interactions of growth and stress networks. In this concise review, we skim the most recent research on nutrient-response pathways.