Журнал сосудистой медицины и хирургии

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Metabolomic Regulation by Oxidative Stress in Cardiac Diseases: An Overview on the State of the Heart

Alan Goncalves Amaral, Aline Marados Santos*

Associations of oxidative stress with Cardio Vascular Diseases (CVDs) are well established; however, the mechanism underlying cardiac damage caused by Reactive Oxygen Species (ROS) is not fully understood. ROS are highly reactive chemical molecules capable of damaging fundamental cellular molecules, including DNA, proteins, and lipids, leading to metabolic alterations, ultimately resulting in cardiomyocyte dysfunction and heart diseases. This review will discuss the current state of metabolomics technologies, the pathological implications of oxidative stress in cardiac tissue, and the metabolic switches in the glucose, lipids, purine and pyrimidines, and glutathione metabolism orchestrated by oxidative stress and their implications on cardiac diseases.