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Metabolic clustering of risk factors: Evaluation of triglyceride-glucose index (TyG index) for evaluation of insulin resistance

Sikandar Hayat Khan

Background: Metabolic syndromes over the years have structured definitions to classify an individual with the dis ease. Literature review suggests insulin résistance is hallmark of these metabolic clustering. While measuring insulin resistance directly or indirectly remains technically difficult in general practice, along with multiple stability issues for insulin, various indirect measures have been suggested by authorities. Fasting triglycerides-glucose (TyG) index is one such marker, which is recently been suggested as a useful diagnostic marker to predict metabolic syndrome. However, limited data is available on the subject with almost no literature from our region on the subject.

Objective:

To correlate TyG index with insulin resistance, anthropometric indices, small dense LDLc, HbA1c and nephropathy To evaluate TyG index as a marker to diagnose metabolic syndrome in comparison to other available markers.