Журнал канцерогенеза и мутагенеза

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Malignant Nodular Hidradenocarcinoma Arising on the Areola of a Male Patient: Case Report of an “Orphan Disease” and Review of the Literature

Eleonora Giorgini, Gregorio Tugnoli, Silvia Aprile, Guido Collina, Silvia Villani, Andrea Biscardi, Simone Maggioli, Eli Avisar and Salomone Di Saverio

Herein we describe a rare case of an “orphan” neoplasm arising on an unusual site.  During the clinical examination, a mass of 3 cm was found on the left areola of a male patient. It was a solid, sliding on the deep layer, with a bluish color mass; therefore an excisional biopsy was performed. The histopathological diagnosis was nodular malignant hidradenoma. An oncological consulting recommended a surgical radicalization through a radical mastectomy. No adjuvant therapy has been given. The patient is alive with no evidence of disease after one-year follow up.