Журнал канцерогенеза и мутагенеза

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Inflammation Related Cancer - Highlights

Shrihari TG

Inflammation is a body response to infectious or physiological agents. During this process aggrevated chronic inflammation mediated release of various mediators such as chemokine’s, cytokines and growth factors by neutrophils, lymphocytes, and macrophages are predominant abundant cells in tumor microenvironment promotes tumor progression. Myeloid derived suppressor cells are immature myeloid progenitor cells upon activation of chronic inflammatory mediators release various factors such as COX2, INOS, ROS, Arginase1 bring about immunosuppression and tumor progression. This article highlight about inflammation related cancer mediated by macrophages and myeloid derived suppressor cells.