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Impairment of Kidney Function among US Hispanics on Tenofovir

Rivera JO, Anaya JP and Cardenas VM

While Hispanic patients represent a growing segment of the HIV-infected US population, nephrotoxicity due to use of tenofovir disoproxil fumarate (TDF) has not been assessed in this patient group. We model the changes by assessing repeated measurements of serum creatinine in106 male Hispanic HIV patients on tenofovir seen in a clinic in El Paso, Texas. We estimated changes in estimated glomerular filtration rates (eGFR) controlling for age, diabetes and hepatitis B chronic infection. We found a deficit in eGFR of 0.5 ml/min/1.73 m2 (95% CI: -0.7, -0.4) per month using the Modification of Diet in Renal Disease (MDRD) equation and 0.4 ml/min/1.73 m2 (95% CI: -0.5, -0.3) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. These findings are consistent with findings from studies reporting data on other ethnic groups that call for the need to monitor kidney function among persons on tenofovir.