Журнал исследований и терапии стволовых клеток

Абстрактный

Human Umbilical Cord [HUC] Vessels: A Novel Substitute for Arterial Bypass Grafting

Biplabendu Talukdar, Swarnendu Datta, Priyodarshi Sengupta, Plaban Mukherjee, Ushnish Chakravarty

Human Umbilical Cord (HUC) vessels and Wharton's jelly containing Mesenchymal Stem Cells may novel substitute for coronary vessels in reconstructive Coronary Artery Bypass Grafting (CABG) surgery. In developing countries, ischemic cardiac tissue injury-related mortality is higher than in developed countries. Organ and tissue transplants may amend the disease but the availability of donor tissue, tissue matching, and procurement of organs are important parameters for successful grafting. Allogenic or autologous preserved HUC vessels along with Wharton’s jelly containing MSCs having human Cord Lining Epithelial Cells (CLECs) which did not express the MHC class II antigen HLA-DR but the non-classical MHC class I antigen HLA-G and HLA-E lacked. HUC-MSC also expresses exosome, Smad protein, TGF beta, BMP also helps in cardiomyocytes regeneration and neo-vascularisation. So the chances of graft rejection is lower and long term survival of graft also initiated. Therefore, human umbilical cord may be used as a substitute for artery or venous graft of vascular and reconstructing surgery. Moreover, chances of recurrent surgical or interventional is diminished for maintaining the patency of coronary vessels.