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HEPATOPROTECTIVE ACTIVITY OF PHYLLANTHUS NIRURI WHOLE PLANT EXTRACT AGAINST STAPHYLOCOCCUS AUREUS INTOXICATED ALBINO RATS

V. RAMAMURTHY ,T ABARNA

In the present study the effect of alcholic extract of the Phyllanthus niruri whole plant on rat biochemical and serum marker enzymes against Staphylococcus aureus induced oxidative stress in the rat liver. Pre and post-treatment with extract showed a dose-dependent reduction of Staphylococcus aureus induced rats were elevated levels of enzyme activity with parallel increase in total protein and bilirubin, indicating the extract could preserve the normal functional status of the liver. In alcoholic extracts treated groups there was statistical significant decrease in the levels of serum bilirubin, SGOT, SGPT and ALP as compared to the hepatotoxic group. In significant reduction in the activity levels of superoxide dismutase, catalase, glutathione peroxidase, gluthaione-s-transferase, and also glutathione reductase content were observed in the liver of S. aureus intoxicated rats over controls. Thus, the results suggest the beneficial role of Phyllanthus niruri might be due to its antioxidative properties against S. aureus infection induced oxidative stress in liver.