Наследственная генетика: текущие исследования

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Genetics of Young Onset Colorectal Cancer

Esha Baichoo and Lisa A Boardman

In the United States, more than 150, 000 cases of colorectal cancers are diagnosed annually, making colorectal cancers a major cause of morbidity and mortality. Hereditary colorectal cancers are thought to account for up to 30% of the total number, 5% of which have a known genetic background. Colorectal cancers occurring at ages less than 50 are considered young-onset and are thought to make up 2% to 8% of all cases. They are often a hallmark of a hereditary cancer predisposition. This review covers both the major and the less common hereditary syndromes associated with young-onset colorectal cancers and provide a brief overview of current genetic testing guidelines in place.