Журнал наномедицины и нанотехнологий

Абстрактный

Drug Nano-particle: A Release Kinetics

Roli Jain, Sandeep Kumar Sukla, Neeti Nema and Archna Panday

Depression is estimated to affect nearly 340 million people worldwide and 18 million people in the US at any given time making it the third most costly and disabling illness in the US. Duloxetine hydrochloride is one of the main antidepressant used as a selective serotonin and nor epinephrine reuptake inhibitor (SSNRI) for oral administration. As it works on central nervous system (CNS), drug should be more available to the cells. To increase the efficacy and solubility drug can be formulated with polymers using nano particle as a drug carriers. In this work we propose and analyzed different approaches to study measuring the size of nano particle and effect of these nano particles on the in vitro kinetics dissolution behavior. The drug obeyed the beers law over the range of 5-50 μg/ml at λmax 230 nm. Drug with PEG 4000 in 6.8 phosphate buffer is proposed good discriminative dissolution media for Duloxitine hydrochloride delayed release formulation. The quantization of drug release studied by UV-Spectrophotometer at 230 nm. Nano particle size and morphology are determined by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). By fitting the dissolution data in various kinetic models find out delayed release formulation of Duloxitine hydrochloride obey the Higuchi model kinetics having linearity range 0.99 and release component ‘n’ obtain by the Korsmyer Pappas model indicate release mechanism followed by the anomalous diffusion process.