Журнал исследований и терапии стволовых клеток

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Differential Transcriptomic and Proteomic Analysis between Embryonic Cells and Aged Cells Confirms that Embryo is a Plethora of Rejuvenating Molecules

Sivarama Prasad Darsi, Satyanarayana Rentala, Sreedhar Surampudi, Ram Reddy Barra, Adi Reddy Kamireddy, Sujesh kumar Darsi, Radhakrishna Nagumanthri

Regenerative medicine has a wide scope, started with direct transplantation of various stems cells into the tissues or organs for functional restoration. In a further development, molecules of Stem cells are used for the treatment of organ function restoration, but they are the source for a few tissue growth factors. As they have limited scope, there is a need for comprehensive methods in treating age-related organ function restoration.

Sexually reproducing organisms pass through the different stage at which it starts their life from zygote to till it becomes a complete organism. Tissue differentiation and organogenesis are not life-long processes; they occur only at the embryonic stage that follows specific gene signatures. Every organ and tissues are unique in their functions; they need specific gene expressions and their proteins for differentiation and development.

Recent studies of comparative transcriptomic analysis of adult human Mesenchymal Stem Cells (MSCs) derived from dental pulp and adipose tissues showed that dental pulp-derived MSCs exhibit gene expression signatures of neuronal growth while adipose tissue-derived MSCs exhibit signatures of angiogenesis and hair growth. This confirms that Stem cells are a limited source for growth factors

This review emphasizes the transcriptomic and proteomic comparison between aged tissue cells and embryonic tissue cells. This comparative compositional analysis is a fruitful approach for tracing rejuvenating or anti-aging and growth factor for the whole organism.