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Development and use of advanced mass spectrometry techniques for the characterization of cellular lipidomic profile of fibroblasts in early on-set Parkinson

Calvano Cosima Damiana

Parkinson’s disease (PD) may be a progressive neurodegenerative disease involving the nigrostriatal pathway; patients’ manifest motor symptoms dysfunction when quite 50% of neurons are lost. Though it’s well recognized that alterations of lipid signaling, and metabolism plays a big role in many human diseases, little is understood about the role of lipids during this specific disease. Recently, it’s been reported that altered lipid pathways within the primary visual area and therefore the anterior cingulate are possible in neurological disorders like PD by analyzing post-mortem tissues from patients in advanced neuronal degeneration stage. Such an approach, however, hinders the identification of the primary neuronal changes