Журнал интеллектуального анализа данных в геномике и протеомике

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Computational Analysis on the Role of GPM6A in Human Thyroid Cancer

Zoya Khalid, Sheema Sameen, Shaukat I Malik and Shehzad S

Thyroid cancer is one of the major cancers around the world. In this study the whole thyroid genome is systematically scanned in order to hit those molecular targets which are highly associated with thyroid cancer. To achieve this goal bioinformatics methodologies are combined. These include the high throughput microarray analysis combined with Serial analysis of gene expression. The results obtained revealed Glycoprotein M6A (GPM6A) as a novel associated gene marker. It belongs to the glycoprotein’s family which plays a major role in cell migration and also known as the major contributors in tumor formation. Moreover the biological pathway of GPM6A is not yet been defined. In this study by assessing the whole biological mechanism the pathway is also inferred .This new drug target will help the biologists in finding the early diagnosis and better treatment for the thyroid cancer patients.