Сердечно-сосудистая фармакология: открытый доступ

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Compliance Amongst Warfarin Users Diagnosed Non-valvular Atrial Fibrillation are We Aware: Prospective Survey

Hashem Mansour*, Rafat Lubbad, Hasan Aboobaid, Khamis Issi

Introduction: Vitamin k antagonists are the most commonly prescribed anticoagulation among non-valvular atrial fibrillation patients. It is indicated for stroke prevention in this group of patients. The aim of this study is to assess patient compliance among NVAF warfarin users.

Method: The study designed as prospective study, conducted in the medical department in Indonesian and Shifa hospital- Palestine. We included patients undergoing oral anticoagulation with VKA diagnosed with NVAF with diabetes, cardiovascular disease aged between 20-85 years old, otherwise were excluded. The laboratory data include
the INR, creatinine clearance, random blood sugar, systolic and diastolic blood pressure, liver chemistry extracted from patient file.

Analysis: Continuous data are presented as the mean ± standard deviation, and the categoric variables were presented as percentage. To find the relationship between quantitative variables we used binary univariate analysis statistically significant results were considered at a two-tailed p-value <0.05. Data were analyzed using SPSS version 20 software.

Finding: The total number was 100 patients, 50% males and the remain females. The results show that 43% of the patients know the risk of the drug while 39% know about the benefit. Only 58% of patients are within the therapeutic INR and 66% do not follow regular INR monitoring. There was 28% of patients are not in contact with any health care providers for drug monitoring. The results also show that 21% of patients do not follow their daily dose and 36% complain of hemorrhage. The results clarify that there exists a positive relationship between a creatinine, diastolic Bp, systolic Bp and INR Since p-value <0.05.

Interpretation: The finding of this study shows that most of our patients' unaware warfarin, so we recommend construction of warfarin clinic for this group of patients for regular follow up with education program with qualified health care provider.