Журнал канцерогенеза и мутагенеза

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Chemokines and Chemokine Receptors Expression in the Adipose Derived Stem Cells (ASCs), Breast Tissues and in Peripheral Blood of Patients with Breast Cancer

Mahboobeh Razmkhah, Mansooreh Jaberipour and Abbas Ghaderi

It has been demonstrated that the tumor angiogenic ability is one of the most important predictors of breast cancer progression. Factors controlling tumor angiogenesis are varied and currently under investigation. Chemokines, which produced by both tumor cells and cells of tumor microenvironment are known with a role in tumor angiogenesis. Here, we examined the expressions of SDF-1/CXCR4/CXCR7, CXCL13/CXCR5, RANTES/CCR5, MCP-1 and CCR7 in adipose derived stem cells (ASCs) and breast cancer tissues of breast cancer patients. Results of ASCs were compared to those from sex matched healthy individuals. Data of breast cancer tissues were compared between stage III and stages I and II tumors. As a result, SDF-1 protein showed higher expression in ASCs from patients with pathological stage III compared to those with pathological stages I and II tumors and normal individuals. In breast cancer tissues, the mRNA expressions of MCP-1 and SDF-1 were 8.4 and 2.6-fold more in patients with stage III than those with stages I and II tumors. RANTES and CXCR4 mRNAs had significantly more expression in tissues of HER2+ compared to HER2- patients (P value = 0.01 and 0.04, respectively). Current information suggest adipose derived stem cells as one of the major players of breast cancer microenvironment which express angiogenic chemokine molecules and contribute to the breast cancer cells growth and progression.