Наследственная генетика: текущие исследования

Абстрактный

Brief Exchanges on Selection of Genomic Regions and Genes Related to Adaptation and Fertility Traits of Two Colombian Creole Cattle Breeds

C. De Leon, R. Martinez

Natural selection and domestication in livestock species are one of the main evolutive changes resulting in phenotypic adaptations; these patterns create genetic signatures within the genome. To discovery signatures and genes involved in adaptation and fertility traits in two Colombian creole cattle breeds Blanco orejinegro (BON) and Sanmartinero (SM) in the present study it was detected selected genomic regions by comparing differences in regional linkage disequilibrium (LD) using 58,868 single nucleotide polymorphisms (SNPs) from BON and 57482 SNPs from SM. Also was estimated the variation of genome-wide LD between populations using the VARLD program. The top 0.1 and 0.01th percentiles of standardized VarLD scores were used as a criterion for all comparisons. Ten regions were detected on chromosomes 3, 5, 11, 15, 18, 21, 22, 23, 25 and 29 and genes in it such as CTDSP2, CES1, CFAP161, CLEC14A, HIPK1, RBM4, KDMID, OLFML3, ATP23, LRRTM1, SLC6A2, DEK, SYT6, KDMID involved in adaptation and fertility traits. These findings open the prospect to develop new studies in other cattle breeds and other livestock species which will serve as support in genetic improvement and conservation programs.