Журнал канцерогенеза и мутагенеза

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Autophagy in Melanoma: A Brief Note

James L Cox

The incidence of melanoma is rising and it remains a very difficult cancer to treat effectively. There is a challenge in treating late-stage melanoma that concerns development of drug resistance to current therapies. Newer therapies will unlock therapeutic resistance by activating alternative cell death pathways in melanoma. Autophagy is a cell survival process for advanced melanoma. Hopefully, newer agents that are being experimentally tested will couple autophagic cell death with other anti-cancer therapies to produce synergistic killing effects for melanoma.