Клиническая и медицинская биохимия

Абстрактный

Assessment of Malnutrition and Inflammatory Status in Cervical Cancer Patients attending Tikur Anbessa Specialized Hospital.

Etsegenet Assefa, Maria Degef, Wondemagegnhu Tigeneh, Ñatesan Gnanasekaran, Mezegebu Legesse, Tadesse Lejisa

Gynecological cancer patients experience malnutrition and Inflammation that play a pivotal role in the progression of cervical cancer. The aim of the present study was to assess malnutrition and inflammatory status in cervical cancer patients through measurement of biochemical markers. Hospital based comparative cross-sectional study was conducted on 50 cervical cancer patients and 50 healthy individuals. Blood was collected and analyzed to gather biochemical and hematological data. Demographic and anthropometric data were also collected and data were statistically analyzed. The mean age was participants 52.4 years. Patients had decreased Albumin, Hemoglobin and Lymphocyte to Monocyte ratio and increased Total Protein, Ferritin, Red cell Distribution Width (RDW), Neutrophils to Lymphocytes ratio and Platelet to Lymphocytes ratio levels than controls group and also those parameters showed in cervical cancer from stage II to stage IV. Albumin negatively correlated with serum ferritin (r=-0.120*, p=0.002) and RDW (r= -0.018*, p=0.001) in cervical cancer patient and negatively correlated with serum total protein (r=0.943*, P<0.001) in control group. NLR positively correlated with PLR (r=0.764**, p=0.000) and LMR (R=1.000**, P=0.000) in cervical cancer patients. Albumin, Total Protein and Ferritin also Hemoglobin, NLR, RDW LMR and PLR may serve as markers for assessment of malnutrition and inflammation and may also use as a prognostic factor in cervical cancer patients.