Фармацевтика Аналитика Акта

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Application of Capillary Isotachophoresis in Phenothiazines Determination

Marzanna Kurzawa, Anna Filipiak-Szok, Aneta Jastrzębska and Edward Szłyk

A capillary isotachophoretic method (cITP) using three electrolyte systems for determination of promethazine, thioridazine and chlorpromazine hydrochlorides in pharmaceutical preparations was demonstrated. Proposed systems were characterised by linearity range 5-100 mg/L with R2 in all cases were higher than 0.999. The elaborated method was tested on pharmaceutical preparations. The recovery values were from 96.5% to 101.3%. The proposed isotachophoretic method is simple with acceptable precision and accuracy and can be suitable for routine analysis of studied biological active compounds.