Журнал биоэквивалентности и биодоступности

Абстрактный

Analysis of Pharmacokinetic & Pharmacodynamic Models in Oral and Transdermal Dosage Forms

Parthasarathi D, Gajendra C, Dattatreya A and Sree Venkatesh Y

Bioavailability is a pharmacokinetic term which refers the extent and speed of absorption of the chemicals content in it. After the absorption the drug plays the important role in which the body react i.e. the pharmacodynamics process. Oral drugs, Transdermal drugs, Lipophilic drugs and combined oral drugs all plays the different role after being absorbed and the mode of absorption is also different through various research. The pharmacokinetic parameters (AUC), (C_max) and dynamic models express the process of drug ADME reports. Various sample analysis is also being done through various instrumentation and databases. Researches and reports reveal the various side effects of few drugs which are taken orally as well as transdermally and the combine effects are being taken into consideration. The main aim is to analyze the process of drug absorption through various parameters, different instruments and mention the side effects after absorptions.