Фармацевтика Аналитика Акта

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An Explicit Review on Quantitative Estimation of Candesartan Cilexetil Employing Various Analytical Techniques

Shantanu Bandyopadhyay, Lohit Bhuria and Devi Lal

Angiotensin II Receptor type 1 antagonists have been widely used in treatment of various disorders like hypertension, heart failure, myocardial infarction and diabetic nephropathy. Over the years, varied analytical methods were developed both in biological fluids as well as dosage forms in order to estimate their desired pharmacological activity. Candesartan being highly lipohpilic with variable oral bioavailability, its estimation in biological fluids is very critical for establishing its subsequent therapeutic efficacy. A few UV spectrophotometeric and volatmmetric techniques have been reported to estimate candesartan in bulk formulations. Additionally, capillary electrophoresis methods provided qualitative and quantitative estimation of candesartan with a few methods being systematically optimized using experimental designs. Ultimately, an overview of different HPLC and LC-MS/MS methods explained the importance of the methods while estimating candesartan in various biological fluids (e.g. plasma, urine, etc.) as well as other studies like, stability studies. This review provides a bird’s eye-view on the various analytical techniques employed for determination of candesartan in both in vitro and in vivo conditions.