Журнал канцерогенеза и мутагенеза

Абстрактный

Amplified Hypoxia Induced Tumor-Cell Death In vitro

Ajay Nair

Cancer is the state of cells marked by unregulated proliferation. There are several characteristic features attributed to its occurrence so as to demarcate itself from the normal tissue system, and one of them is Angiogenesis, that ensures its continued survival in the body. Angiogenesis, in the recent past has become a nucleus of notice and has hence opened new portals in the realm of cancer therapy. Anti-Angiogenic studies have made hysteric escalations in the evolution of effectual anti-cancer drugs. This review, in an attempt to contribute to the contemporary therapies, talks about a novel therapeutic approach of targeting tumor cells by depriving oxygen from them through increased hypoxia which surpasses their minimum requirement for oxygen; the latter achieved by interfering at the interface of oxygen diffusion between the blood vessels and tumor cells.