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A Rare Case of Possible, Food, Drug and Acrylamide Pharmacological Interactions

Restrepo C, Gómez V and Galvis Pareja D

Fibromyalgia is a chronic disorder with a broad spectrum of clinical manifestations such as muscular weakness and pain, fatigue and sleep disturbances. In this case we describe a female patient, frequent tea consumer with a classic presentation of fibromyalgia, initially treated with paracetamol+caffeine, due to poor control of symptoms cyclobenzaprine was prescribed, after a few months the symptoms got worse and duloxetine was added to the pharmacotherapy, few days later her muscle pain and weakness worsened, this could be explained by either the acrylamide from tea that mimics the fibromyalgia symptoms or food-drug interactions. Palpitations, insomnia, restless legs syndrome and anxiety associated to a mild serotoninergic syndrome could be due to drug-drug interactions. The novelty of this article is the presence of neurotoxic acrylamide in tea and the interactions it may have, not only with disease but with conventional pharmacotherapy also. It is of relevance to raise awareness about the possible toxic compounds found in food.